Sorry, these notes in are draft. No time to make it better. The theory
I am referring to is a model that relates the benefits of calorie
restriction (CR) and related regimens to energy utilization in
In general, I'm in agreement with Mayo about sleep schedule, but
occasional mild sleep deprivation may also be worthwhile to do. My
current schedule allows for a healthy amount of sleep every night, but
I'm up quite late almost every Thursday. I get more done this way. If
you are getting regular healthy sleep, try pulling one or two
all-nighters. It is worth the experience. Truncating your sleep
schedule will shorten your lifespan, but one or two is unlikely to
hurt. In general, get the right amount of sleep, and prolong your
We sometimes need to remind our associates that those who wish to cut
into our healthy sleep schedule do not have our interest at heart. Get
the right amount of sleep. You will be far more content, if you can
give your work the attention that it deserves.
People who are getting healthful amounts of exercise, water, food, and
sleep may get additional benefits by straining the margins abit. Just
be careful to avoid deranging your healthful routine. Keep the aim in
mind. I've worked up some theory about this analogizing from CR.
fasting, sleep deprivation, heavy exercise, & water fasting have
related effects. It doesn't mean that you shouldn't try occasional
feasting, sleeping in, missing a workout, and drinking a little too
much water. ;-)
Current research indicates people who regularly get the right amount
of sleep are more healthy, perhaps since most people deviate too
often. The theory indicates a person getting 5 or less hours of sleep
every night will have a significantly shorter lifespan. It is like
starving. The theory is supported by fact that people who are sleep
deprived are also frequently over-eating, a way of compensating for
loss of rest.
In the days of frequent predation, sleep was often a scarcity. Too
much exercise can be damaging, rather in the same way as starving, by
wasting the body. It pays to study up on your exercise regimen. Not
enough exercise creates similar problems as too much food, or
unhealthful diet, or too much sleep. The body unpacks the hazardous
operations during sleep. There is housekeeping, as it were, that is
best done on relaxed joints and muscles. Too much sleep (or too
little) is a load of hazard. If you are sleep deprived, the body is
unfortunately forced to do these operations on active joints and
muscles, leading to damage. The damage is expected to correlate well
with aging damage. It would be interesting to look at muscle loss in
sleep deprived people. It is wasting. The body later forced to cut out
the damaged areas. The body usually cuts tissues with hydrogen
peroxide. This could explain some of the joint problems in sleep
deprived people. Arthritis.
Those who are getting too much sleep face other problems, which are
about as worrisome. It is common sense that they need more activity.
My current view is water fasting facilitates inter-cell communication.
It can take several days after the fast to set the new norm. Neurons.
My thesis was on muscle,&I think about it alot. Damaged muscle means
damaged mitochondria. For a cell, this is like a nuclear reactor dump.
Muscle has adapted to sustain the damage during normal exercise, but
sleep is required for many repairs. It is like remodeling a house.
Bust out the walls. It is necessary for the muscle to be at rest, or
the situation will be worse, not better. Keep your water, food, sleep
and exercise in the healthful range, or else the body will mistakenly
do these hazardous ops at the wrong time.
I commute by bicycle, about 50 minutes per day. It is great, but it is
not enough exercise. I've been trying to expand my program. I started
jogging a couple of years ago. After a couple of weeks, I badly
strained a fiber bundle in the calf muscle, and it got me thinking
Fortunately, muscle damage is comparatively easy to recover quickly,
and the calf came back stronger. I'm over 50, and yet another example
that muscle loss can be reversed. If you had a way to reverse the
effects of aging, would you do it?
If we could think more about how athletic muscle is packed with
mitochondria, it would be beneficial to many people. There is a hazard
there. It takes much longer for joints and bones to recover from
damage, but it is possible to recover them too. I've recovered all of
my lost muscle&more. Now, I notice the mild burn from the hydrogen
peroxide. I'm hoping for more beneficial gains.
Our bodies get their best remodeling in the dark, when we are resting
and sleeping, at night. Not too much though. ;-) Of course, the
mitochondria issue is not just for athletes. It relates to my calf
problem, but also to serious problems like heart disease. Differential
strain likely explains many of the problems in tissue, and this
relates directly to the mitochondrial diversity. Filament damage
likely takes out the mitochondria that are not keeping up in a kind of
natural selection. Ach, sore muscles!
I recommend pushing the exercise regimen to the upper beneficial
limit. It is like CR; not as good, but the benefit is there. It is
likely a vigorous program occasionally pushing margins, will result in
a healthy mitochondria population overall, not just in muscle.
Remember; sleep, water, food, exercise. Think like a scientist.
I made more rapid progress with strength training & distance bicycling
than what is predicted in the literature. I'm attributing this to
CR-related, peroxide quenching, flavonoids. Some do not favor life
extension, because they're not enjoying life. Take care of your body,&
you will enjoy life more, and live longer too If we keep ourselves
healthy, we will get more done in the short time that we have.
Longevity and knowledge may be among the best human pursuits. You
don't get any more by stealing them from others.
Michael L. Love